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However, the attribution was disputed by reports showing the plant extracts from fresh leaves contained another substance more behaviourally active than cathine. In , the related alkaloid cathinone was isolated, and its absolute configuration was established in Cathinone is not very stable and breaks down to produce cathine and norephedrine. These chemicals belong to the PPA phenylpropanolamine family, a subset of the phenethylamines related to amphetamines and the catecholamines epinephrine and norepinephrine. However, both the side effects and the addictive properties of methcathinone are much stronger than those associated with khat use. Thus, harvesters transport khat by packaging the fresh leaves and stems in plastic bags or wrapping them in banana leaves to preserve their moisture and keep the cathinone potent. It is also common for them to sprinkle the plant with water frequently or use refrigeration during transportation. When the khat leaves are chewed, cathine and cathinone are released and absorbed through the mucous membranes of the mouth as well as the lining of the stomach.

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